Optimer® delivers hot start performance for KOD DNA Polymerase

Optimer delivers the hot start control your high-fidelity PCR enzymes need.

Download the application note to learn how:

  • Optimer binders inhibit both polymerase and exonuclease activity at ambient temperature and release on thermocycling, providing temperature-sensitive hot start control of KOD DNA Polymerase
  • a unique dual-domain binding mode simultaneously engages both enzymatic domains of KOD, providing a mechanism for comprehensive inhibition with a single reagent
  • a portfolio of licensable Optimer binders with varying inhibitory profiles have been developed
  • chemical stabilisation preserves full inhibitory function and supports robust commercial formulation and manufacture

Interested in Optimer inhibitors for other enzymes?

The same platform that delivered hot start control for KOD DNA Polymerase can be applied to virtually any enzyme target. Optimer binders can be rapidly developed to inhibit a broad range of enzymes with high selectivity and tunable activity profiles. Contact Aptamer Group to discuss licensing or a custom Optimer development programme for your target enzyme.

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